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KMID : 1100220030020020125
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Dementia and Neurocognitive Disorders
2003 Volume.2 No. 2 p.125 ~ p.130
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Comparison of Risk Factor Profiles between Lacunar Type and Non-Lacunar Type of Subcortical Ischemic Vascular Dementia
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Bae Hee-Joon
Jeong Jee-Hyang
Yu Kyung-Ho
Na Duk-Lyul
Kim Sang-Yun
Choi Kyoung-Gyu
Yang Dong-Won
Son Eui-Ju
Yi Sang-Doe
Kim Jae-Woo
Park Kyung-Won
Kim Eung-Gyu
Lee Jae-Hong
Park Mee-Young
Han Il-Woo
Hahm Dong-Seok
Choi Mun-Seong
Ha Choong-Kun
Choi Seong-Hye
Lee Ae-Young
Han Seol-Heui
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Abstract
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Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these, subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes.
Methods: We divided 47 subjects (22 males; mean age, 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups: one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group). Clinical characteristics and laboratory findings of two groups were compared.
Results: Nineteen of 47 patiens (40%) belonged to the lacune group. The lacune and non-lacune groups did not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia, heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension, stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol, LDL cholesterol, creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking, alcohol, hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with nonlacune group (p<0.1). Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes.
Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits, hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
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KEYWORD
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Subcortical ischemic vascular dementia, Risk factors, Lacunar
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